Lateral-directional stability and control characteristics of the Quiet Short-Haul Research Aircraft (QSRA)

The results are presented of flight experiments to determine the lateral-directional stability and control characteristics of the Quiet Short-Haul Research Aircraft (QSRA), an experimental aircraft designed to furnish information on various aerodynamic characteristics of a transport type of airplane that makes use of the upper-surface blown (USB) flap technology to achieve short takeoff and landing (STOL) performance. The flight program designed to acquire the data consisted of maneuvers produced by rudder and control-wheel inputs with the airplane in several configurations that had been proposed for landing approach and takeoff operation. The normal stability augmentation system was not engaged during these maneuvers. Time-history records from the maneuvers were analyzed with a parameter estimation procedure to extract lateral-directional stability and control derivatives. For one aircraft configuration in which the USB flaps were deflected 50 deg, several maneuvers were performed to determine the effects of varying the average angle of attack, varying the thrust coefficient, and setting the airplane's upper surface spoilers at a 13 deg symmetrical bias angle . The effects on the lateral characteristics of deflecting the spoilers were rather small and generally favorable. The data indicate that for one test, conducted at low thrust (a thrust coefficient of 0.38), compared with results from tests at thrust coefficients of 0.77 and larger, there was a significant decrease in the lateral control effectiveness, in the yaw damping and in the directional derivative. The directional derivative was also decreased (by about 30 percent) when the average angle of attack of the test was increased from 3 to 16 deg

Macroeconometric Analysis of Economic Activity in Thailand, 1962–1974

This report summarizes work completed to date on macro models of the Thai economy. The project is a cooperative one conducted by the Division of Agricultural Economics (DAE) of the Ministry of Agriculture and Cooperatives, Royal Thai Government, and the Center for Agricultural and Rural Development (CARD) and the Department of Economics of Iowa State University. Funded by the Agency for International Development and the Royal Thai Government, it is one phase of a sector analysis project being undertaken in the DAE to provide models which can aid development and policies, particularly for Thai agriculture. A series of macro models for the Thai economy have been undertaken to supplement the various models being developed for the agricultural sector of Thailand. These activities were undertaken not only because of the importance of national economic policies on employment, prices, and other variables in agriculture, but also because various policies enacted in behalf of agriculture also impact on other sectors of the economy. The model reported is the first generation of a set of macro economic models which may be specified and quantified for the Thai economy. The current model is now being linked with a national programming model developed for the agricultural sector.https://lib.dr.iastate.edu/dae-card_sectoranalysis/1002/thumbnail.jp

Reactions of poly(ethylene glycol) cations with iodide and perfluorocarbon anions

AbstractMultiply charged poly(ethylene glycol) ions of the form (M+nNa)n+ derived from electrospray ionization have been subjected to reactions with negative ions in the quadrupole ion trap. Mixtures of multiply charged positive ions ranging in average mass from about 2000 to about 14,000 Da were observed to react with perfluorocarbon anions by either proton transfer or fluoride transfer. Iodide anions reacted with the same positive ions by attachment. In no case was fragmentation of the polymer ion observed. In all cases, the multiply charged positive ion charge states could be readily reduced to +1, thereby eliminating the charge state overlap observed in the normal electrospray mass spectrum. With all three reaction mechanisms, however, the +1 product ions were comprised of mixtures of products with varying numbers of sodium ions, and in the case of iodide attachment and fluoride transfer, varying numbers of halogen anions. These reactions shift the mass distributions to higher masses and broaden the distributions. The extents to which these effects occur are functions of the magnitudes of the initial charges and the width of the initial charge state distributions. Care must be taken in deriving information about the polymer molecular weight distribution from the singly charged product ions arising from these ion/ion reactions. The cluster ions containing iodide were shown to be intermediates in sodium ion transfer. Dissociation of the adduct ions can therefore lead to a +1 product ion population that is comprised predominantly of M+Na+ ions. However, a strategy based on the dissociation of the iodide cluster ions is limited by difficulties in dissociating high mass-to-charge ions in the quadrupole ion trap

Geomorphological control on boulder transport and coastal erosion before, during and after an extreme extra-tropical cyclone

Extreme wave events in coastal zones are principal drivers of geomorphic change. Evidence of boulder entrainment and erosional impact during storms is increasing. However, there is currently poor time coupling between pre- and post-storm measurements of coastal boulder deposits. Importantly there are no data reporting shore platform erosion, boulder entrainment and/or boulder transport during storm events – rock coast dynamics during storm events are currently unexplored. Here, we use high-resolution (daily) field data to measure and characterise coastal boulder transport before, during and after the extreme Northeast Atlantic extra-tropical cyclone Johanna in March 2008. Forty-eight limestone fine-medium boulders (n = 46) and coarse cobbles (n = 2) were tracked daily over a 0.1 km2 intertidal area during this multi-day storm. Boulders were repeatedly entrained, transported and deposited, and in some cases broken down (n = 1) or quarried (n = 3), during the most intense days of the storm. Eighty-one percent (n = 39) of boulders were located at both the start and end of the storm. Of these, 92% were entrained where entrainment patterns were closely aligned to wave parameters. These data firmly demonstrate rock coasts are dynamic and vulnerable under storm conditions. No statistically significant relationship was found between boulder size (mass) and net transport distance. Graphical analyses suggest that boulder size limits the maximum longshore transport distance but that for the majority of boulders lying under this threshold, other factors influence transport distance. Paired analysis of 20 similar sized and shaped boulders in different morphogenic zones demonstrates that geomorphological control affects entrainment and transport distance – where net transport distances were up to 39 times less where geomorphological control was greatest. These results have important implications for understanding and for accurately measuring and modelling boulde

Ion-ion proton transfer reactions of bio-ions involving noncovalent interactions: Holomyoglobin

Multiply protonated horse skeletal muscle holomyoglobin and apomyoglobin have been subjected to ion-ion proton transfer reactions with anions derived from perfluoro-1,3dimethylcyclohexane in a quadrupole ion trap operated with helium as a bath gas at 1 mtorr. Neither the apomyoglobin nor holomyoglobin ions show any sign of fragmentation associated with charge state reduction to the 1 + charge state. This is particularly noteworthy for the holomyoglobin ions, which retain the noncovalently bound heme group. For example, no sign of heme loss is associated with charge state reduction from the 9 + charge state of holomyoglobin to the 1 + charge state despite the eight consecutive highly exothermic proton transfer reactions required to bring about this charge change. This result is consistent with calculations that show the combination of long ion lifetime and the high ion-helium collision rate relative to the ion-ion collision rate makes fragmentation unlikely for high mass ions in the ion trap environment even for noncovalently bound complexes of moderate binding strength. The ion-ion proton transfer rates for holo- and apomyoglobin ions of the same charge state also were observed to be indistinguishable, which supports the expectation that ion-ion proton transfer rates are insensitive to ion structure and are determined primarily by the attractive Coulomb field

Mapping the Constrained Coding Regions in the human genome to their corresponding proteins

Constrained Coding Regions (CCRs) in the human genome have been derived from DNA sequencing data of large cohorts of healthy control populations, available in the Genome Aggregation Database (gnomAD) [1]. They identify regions depleted of protein-changing variants and thus identify segments of the genome that have been constrained during human evolution. By mapping these DNA-defined regions from genomic coordinates onto the corresponding protein positions and combining this information with protein annotations, we have explored the distribution of CCRs and compared their co-occurrence with different protein functional features, previously annotated at the amino acid level in public databases. As expected, our results reveal that functional amino acids involved in interactions with DNA/RNA, protein-protein contacts and catalytic sites are the protein features most likely to be highly constrained for variation in the control population. More surprisingly, we also found that linear motifs, linear interacting peptides (LIPs), disorder-order transitions upon binding with other protein partners and liquid-liquid phase separating (LLPS) regions are also strongly associated with high constraint for variability. We also compared intra-species constraints in the human CCRs with inter-species conservation and functional residues to explore how such CCRs may contribute to the analysis of protein variants. As has been previously observed, CCRs are only weakly correlated with conservation, suggesting that intraspecies constraints complement interspecies conservation and can provide more information to interpret variant effects

A Model for the Analysis of Caries Occurrence in Primary Molar Tooth Surfaces

Recently methods of caries quantification in the primary dentition have moved away from summary ‘whole mouth’ measures at the individual level to methods based on generalised linear modelling (GLM) approaches or survival analysis approaches. However, GLM approaches based on logistic transformation fail to take into account the time-dependent process of tooth/surface survival to caries. There may also be practical difficulties associated with casting parametric survival-based approaches in a complex multilevel hierarchy and the selection of an optimal survival distribution, while non-parametric survival methods are not generally suitable for the assessment of supplementary information recorded on study participants. In the current investigation, a hybrid semi-parametric approach comprising elements of survival-based and GLM methodologies suitable for modelling of caries occurrence within fixed time periods is assessed, using an illustrative multilevel data set of caries occurrence in primary molars from a cohort study, with clustering of data assumed to occur at surface and tooth levels. Inferences of parameter significance were found to be consistent with previous parametric survival-based analyses of the same data set, with gender, socio-economic status, fluoridation status, tooth location, surface type and fluoridation status-surface type interaction significantly associated with caries occurrence. The appropriateness of the hierarchical structure facilitated by the hybrid approach was also confirmed. Hence the hybrid approach is proposed as a more appropriate alternative to primary caries modelling than non-parametric survival methods or other GLM-based models, and as a practical alternative to more rigorous survival-based methods unlikely to be fully accessible to most researchers

Characterization of Low Frequency Auditory Filters

The purpose of this study is to characterize auditory filters at low frequencies, defined as below about 100 Hz. Three experiments were designed and executed. They were conducted in the Exterior Effects Room at the NASA Langley Research Center, a psychoacoustic facility designed for presentation of aircraft flyover sounds to groups of test subjects. The first experiment measured 36 subjects hearing threshold for pure tones (at 25, 31.5, 40, 50, 63 and 80 Hz) in quiet conditions. The subjects, male and female, had a wide age range. This experiment allowed the performance of the test facility to be assessed and also provided screened test subjects for participation in subsequent experiments. The second and third experiments used 20 and 10 test subjects, respectively, and measured psychophysical tuning curves (PTCs) that describe auditory filters with center frequencies of approximately 63 and 50 Hz. The latter is assumed to be the lowest (bottom) auditory filter; thus, sounds at frequencies below about 50 Hz are perceived via the lower skirt of this lowest filter. All experiments used an adaptive, three-alternative forced-choice test procedure using either variable level tones or variable level, narrowband noise maskers. Measured PTCs were found to be very similar to other recently published data, both in terms of mean values and intersubject variation, despite different experimental protocols, different test facilities, and a wide range in subjects age

Some Issues in Resolution using an Imperfect Gold Standard

1 online resource (PDF, 15 pages